Bases genéticas, moleculares y bioquímicas del envejecimiento auditivo ¿Qué nos enseñan los modelos experimentales
DOI:
https://doi.org/10.51445/sja.auditio.vol6.2022.0084Palabras clave:
apoptosis, estrés oxidativo, neuroiflamación, modelos animales, presbiacusiaResumen
La presbiacusia afecta a una de cada tres personas mayores de 65 años y constituye el déficit neurosensorial más prevalente. Antecede a la aparición de la fragilidad cognitiva, la acelera y se asocia con un mayor riesgo de padecer enfermedades neurodegenerativas como la demencia o el Alzheimer. La aparición y evolución de la presbiacusia están influidas por factores genéticos, todavía poco conocidos, y ambientales, entre los que destacan la exposición a ruido excesivo o a sustancias ototóxicas. En la actualidad no disponemos de tratamientos farmacológicos eficaces para prevenir o tratar la presbiacusia, por lo que la investigación en este campo es prioritaria. En este contexto, los modelos animales son una herramienta esencial para: a) identificar nuevos genes de presbiacusia, b) comprender las bases celulares y moleculares del envejecimiento auditivo, y c) definir nuevas dianas terapéuticas y evaluar posibles tratamientos.
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Derechos de autor 2022 Blanca Cervantes, Jose M. Bermúdez-Muñoz, Carmen Ruiz-García, Luis Lassaletta, Julio Contreras, Silvia Murillo-Cuesta, Isabel Varela-Nieto
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Artículos publicados después de 2020
Los autores retienen el copyright y dan permiso y derecho a la revista para publicar su primera publicación bajo licencia, si no se expresa lo contrario. Creative Commons Attribution License la cual permite a otros el compartir siempre que se de reconocimiento a los autores de la publicación en esta revista. Si los autores deseasen aplicar ciertas restricciones en su permiso para usos no comerciales u obras derivadas, éstos podrán elegir entre las siguientes licencias:
https://creativecommons.org/about/cclicenses/
Publicaciones 2001-2020
Los textos publicados en esta revista en la seccion de "AUDITIO 2001-2020 están sujetos –si no se indica lo contrario– a una licencia de Reconocimiento 3.0 España de Creative Commons. Puede copiarlos, distribuirlos, comunicarlos públicamente, hacer obras derivadas y usos comerciales siempre que reconozca los créditos de las obras (autoría, nombre de la revista, institución editora) de la manera especificada por los autores o por la revista. La licencia completa se puede consultar en http://creativecommons.org/licenses/by/3.0/es/deed.es.
AUDITIO | Spanish Journal of Audiology
