Genetic, molecular and biochemical basis of auditory aging: lessons from experimental models


  • Blanca Cervantes Facultad de Medicina, Universidad Anáhuac, Puebla, México
  • Jose M. Bermúdez-Muñoz Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM, Madrid, España; Centro de Investigación Biomédica en Red, Instituto de Salud Carlos III, Madrid, España
  • Carmen Ruiz-García Servicio ORL, Hospital Universitario La Paz, Madrid, España
  • Luis Lassaletta Servicio ORL, Hospital Universitario La Paz, Madrid, España; Instituto de Investigación Hospital Universitario La Paz, Madrid, España; ; Centro de Investigación Biomédica en Red, Instituto de Salud Carlos III, Madrid, España
  • Julio Contreras Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, España; Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM, Madrid, España; ; Centro de Investigación Biomédica en Red, Instituto de Salud Carlos III, Madrid, España
  • Silvia Murillo-Cuesta Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, ISCiii)
  • Isabel Varela-Nieto Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM, Madrid, España; Centro de Investigación Biomédica en Red, Instituto de Salud Carlos III, Madrid, España



ARHL, apoptosis, oxidative stress, neuroinflamation, animal models


Age-related hearing loss (ARHL) affects one in three people older than 65 years and is the most prevalent sensorineural deficit. This type of hearing loss precedes and accelerates the onset of cognitive impairment and is associated with an increased risk for neurodegenerative diseases such as dementia and Alzheimer disease. The onset and progression of ARHL is influenced by genetic factors, which are still poorly understood, and environmental factors, which in particular include exposure to excessive noise and ototoxic substances. At present, no effective drug treatments are available for ARHL prevention or treatment, and therefore research in this field is a priority. In the research field, animal models offer a crucial tool for i) identifying new genes associated with ARHL, ii) understanding the cellular and molecular basis of auditory ageing and iii) defining new therapeutic targets and evaluating candidate treatments.


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How to Cite

Cervantes, B., Bermúdez-Muñoz, J. M., Ruiz-García, C., Lassaletta, L., Contreras, J., Murillo-Cuesta, S., & Varela-Nieto, I. (2022). Genetic, molecular and biochemical basis of auditory aging: lessons from experimental models. Auditio, 6, e84.



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